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Zopiclone

Zopiclone Overview

Description:
Zopiclone is a prescription medication commonly used for the short-term treatment of insomnia or difficulty sleeping. It helps initiate and maintain sleep by acting on the central nervous system.

DrugBank ID:
DB01198

Modality:
Small molecule

Explore a selection of our essential drug information below, or

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A dose-range finding study of zopiclone in insomniac patients

1. Professional / Academic

Evaluation of Zopiclone Dose Ranges in Patients with Insomnia

2. More Descriptive

Investigating Optimal Dosage of Zopiclone for the Treatment of Insomnia

3. Concise / Journal-Style

Dose-Range Study of Zopiclone in Insomnia Patients

4. Clinical Trial-Oriented

A Clinical Evaluation of Zopiclone Dosage Ranges in Individuals with Insomnia

Zopiclone Overview

Mechanism of Action

Pharmacological Effects

Dependence and Withdrawal

Important: Unlike high-dose benzodiazepine withdrawal, zopiclone withdrawal rarely causes seizures or life-threatening complications—but severe psychological symptoms (like panic or agitation) can occur and lead to emergency room visits.

Clinical Considerations

Zopiclone UK

Dosage Forms

💊 Always check the Patient Information Leaflet (PIL) included in the medication box for your specific dose and formulation.

Where to Find More Information

You can access official PILs and detailed drug data at:

Need Help or Have Questions?

Reporting Side Effects

If you experience unexpected or serious side effects, report them to the MHRA Yellow Card Scheme:
🔗 https://yellowcard.mhra.gov.uk

This helps monitor drug safety across the UK.

More Resources

Trade namesImovane, Zimovane, Dopareel, others
AHFS/Drugs.comInternational Drug Names
Pregnancy
category		AU: C
Routes of
administration		Oral tablets, 3.75 mg or 7.5mg (UK), 5 mg, 7.5 mg, or 10 mg (JP)
ATC codeN05CF01 (WHO)
Legal status
Legal statusAU: S4 (Prescription only)BR: Class B1 (Psychoactive drugs)[1]CA: ℞-onlyNZ: Class CUK: Class CUS: Schedule IVIn general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability75–80%[2]
Protein binding52–59%
MetabolismHepatic through CYP3A4 and CYP2E1
Elimination half-life~5 hours (3.5–6.5 hours)
~7–9 hours for 65+ years old
ExcretionUrine (80%)
Identifiers
IUPAC name
CAS Number43200-80-2 
PubChem CID5735
IUPHAR/BPS7430
DrugBankDB01198 
ChemSpider5533 
UNII03A5ORL08Q
KEGGD01372 
ChEBICHEBI:32315 
ChEMBLChEMBL135400 
PDB ligandZPC (PDBe, RCSB PDB)
CompTox Dashboard (EPA)DTXSID4041155 
ECHA InfoCard100.051.018 
Chemical and physical data
FormulaC17H17ClN6O3
Molar mass388.81 g·mol−1

References

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